OLFACTORY RECEPTOR NEURONS USE GAIN CONTROL AND COMPLEMENTARY KINETICS TO ENCODE INTERMITTENT ODORANT STIMULI

Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli

Insects find food and mates by navigating odorant plumes that can be highly intermittent, with intensities and durations that vary rapidly over orders of magnitude.Much is known about olfactory responses to pulses and steps, but it remains unclear how olfactory receptor neurons (ORNs) detect the intensity and timing of Main Tub Bearing natural stim

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Beyond Gap Junction Channel Function: the Expression of Cx43 Contributes to Aldosterone-Induced Mesangial Cell Proliferation via the ERK1/2 and PKC Pathways

Aims: This study aimed to explore the precise mechanism and signaling pathways of mesangial cell (MC) proliferation from a new point of view considering Connexin 43 (Cx43).Methods: MC proliferation was measured by the incorporation of 3H-thymidine (3H-TdR).Cx43 was over-expressed in MC cells using lipofectamine 2000, and the expression level was te

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Selection Pressures on RNA Sequences and Structures

With the discovery of increasingly more functional noncoding RNAs (ncRNAs), it becomes eminent to more strongly consider them as important players during species evolution.Although tests for negative selection of ncRNAs already exist since the beginning of this century, the SSS-test is the first one for also investigating positive selection.When an

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